Structural Determinants for Activity of Glucagon-like Peptide-2†
نویسندگان
چکیده
منابع مشابه
Structural determinants for activity of glucagon-like peptide-2.
Glucagon-like peptide-2 (GLP-2) is a 33 amino acid gastrointestinal hormone that regulates epithelial growth in the intestine. Dipeptidylpeptidase IV cleaves GLP-2 at the position 2 alanine, resulting in the inactivation of peptide activity. To understand the structural basis for GLP-2 action, we studied receptor binding and activation for 56 GLP-2 analogues with either position 2 substitutions...
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Multiple peptide hormones produced within the gastrointestinal system act also in the central nervous system and aid in the regulation of energy homeostasis and metabolism. The list of these peptides is progressively increasing and includes glucagon-like peptide 2 (GLP-2) as an anorexigenic factor. GLP-2 is released from enteroendocrine L-cells following food intake and its principal target is ...
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ژورنال
عنوان ژورنال: Biochemistry
سال: 2000
ISSN: 0006-2960,1520-4995
DOI: 10.1021/bi000497p